[HTML][HTML] Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/1 mouse model of Huntington's …
I Rattray, EJ Smith, WR Crum, TA Walker, R Gale… - PloS one, 2013 - journals.plos.org
Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin
(HTT) gene. The R6 mouse models of HD express a mutant version of exon 1 HTT and
typically develop motor and cognitive impairments, a widespread huntingtin (HTT)
aggregate pathology and brain atrophy. Unlike the more commonly used R6/2 mouse line,
R6/1 mice have fewer CAG repeats and, subsequently, a less rapid pathological decline.
Compared to the R6/2 line, fewer descriptions of the progressive pathologies exhibited by …
(HTT) gene. The R6 mouse models of HD express a mutant version of exon 1 HTT and
typically develop motor and cognitive impairments, a widespread huntingtin (HTT)
aggregate pathology and brain atrophy. Unlike the more commonly used R6/2 mouse line,
R6/1 mice have fewer CAG repeats and, subsequently, a less rapid pathological decline.
Compared to the R6/2 line, fewer descriptions of the progressive pathologies exhibited by …
[HTML][HTML] Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6/2 mouse model of HD
I Rattray, E Smith, R Gale, K Matsumoto, GP Bates… - PloS one, 2013 - journals.plos.org
Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin
(HTT) gene. The R6/2 mouse model of HD expresses a mutant version of exon 1 HTT and
develops motor and cognitive impairments, a widespread huntingtin (HTT) aggregate
pathology and brain atrophy. Despite the vast number of studies that have been performed
on this model, the association between the molecular and cellular neuropathology with brain
atrophy, and with the development of behavioral phenotypes remains poorly understood. In …
(HTT) gene. The R6/2 mouse model of HD expresses a mutant version of exon 1 HTT and
develops motor and cognitive impairments, a widespread huntingtin (HTT) aggregate
pathology and brain atrophy. Despite the vast number of studies that have been performed
on this model, the association between the molecular and cellular neuropathology with brain
atrophy, and with the development of behavioral phenotypes remains poorly understood. In …