The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders
DE Comings, BG Comings, D Muhleman, G Dietz… - Jama, 1991 - jamanetwork.com
Objective.—The A1 allele of theTaqI polymorphism of the dopamine D 2 receptor (DRD2)
gene has been earlier reported to occur in 69% of alcoholics, compared with 20% of
controls. Other research has reported no significant difference in the prevalence of the A1
allele in alcoholics vs controls and no evidence that theDRD2gene was linked to alcoholism.
We hypothesized that these seemingly conflicting results might be because increases in the
prevalence of the A1 allele may not be specific to alcoholism. Thus, we examined other …
gene has been earlier reported to occur in 69% of alcoholics, compared with 20% of
controls. Other research has reported no significant difference in the prevalence of the A1
allele in alcoholics vs controls and no evidence that theDRD2gene was linked to alcoholism.
We hypothesized that these seemingly conflicting results might be because increases in the
prevalence of the A1 allele may not be specific to alcoholism. Thus, we examined other …