[HTML][HTML] Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response
A Konishi, J Suzuki, M Kuwahara, A Matsumoto… - Biochemical and …, 2022 - Elsevier
A Konishi, J Suzuki, M Kuwahara, A Matsumoto, S Nomura, T Soga, T Yorozuya…
Biochemical and Biophysical Research Communications, 2022•ElsevierAbstract Glucocorticoids (GCs), immunosuppressive, and anti-inflammatory agents have
various effects on T cells. However, the long-term influence of GCs on the T cell-mediated
immune response remain to be elucidated. We demonstrated that the administration of GC
during the TCR-mediated activation phase induced long-lasting suppression of glycolysis,
even after the withdrawal of GC. The acquisition of the effector functions was inhibited, while
the expression of PD-1 was increased in CD8 T cells activated in the presence of GC …
various effects on T cells. However, the long-term influence of GCs on the T cell-mediated
immune response remain to be elucidated. We demonstrated that the administration of GC
during the TCR-mediated activation phase induced long-lasting suppression of glycolysis,
even after the withdrawal of GC. The acquisition of the effector functions was inhibited, while
the expression of PD-1 was increased in CD8 T cells activated in the presence of GC …
Abstract
Glucocorticoids (GCs), immunosuppressive, and anti-inflammatory agents have various effects on T cells. However, the long-term influence of GCs on the T cell-mediated immune response remain to be elucidated. We demonstrated that the administration of GC during the TCR-mediated activation phase induced long-lasting suppression of glycolysis, even after the withdrawal of GC. The acquisition of the effector functions was inhibited, while the expression of PD-1 was increased in CD8 T cells activated in the presence of GC. Furthermore, adoptive transfer experiments revealed that GC-treated CD8 T cells reduced memory T cell formation and anti-tumor activity. These findings reveal that GCs have long-lasting influence on the T cell-mediated immune response via modulation of T cell metabolism.
Elsevier
