Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target
G Alvisi, A Termanini, C Soldani, F Portale… - Journal of …, 2022 - Elsevier
Background & Aims The landscape and function of the immune infiltrate of intrahepatic
cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains poorly
characterized, limiting development of successful immunotherapies. Herein, we aimed to
define the molecular characteristics of tumor-infiltrating leukocytes with a special focus on
CD4+ regulatory T cells (Tregs). Methods We used high-dimensional single-cell
technologies to characterize the T-cell and myeloid compartments of iCCA tissues …
cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains poorly
characterized, limiting development of successful immunotherapies. Herein, we aimed to
define the molecular characteristics of tumor-infiltrating leukocytes with a special focus on
CD4+ regulatory T cells (Tregs). Methods We used high-dimensional single-cell
technologies to characterize the T-cell and myeloid compartments of iCCA tissues …
