[HTML][HTML] Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas
JY Liau, JC Lee, JH Tsai, CY Yang, TL Liu, ZL Ke… - Modern Pathology, 2015 - Elsevier
According to cytogenetic aberrations, sarcomas can be categorized as complex or simple
karyotype tumors. Alternative lengthening of telomeres is a telomere-maintenance
mechanism common in sarcomas. Recently, this mechanism was found to be associated
with loss of either α-thalassemia/mental retardation syndrome X-linked (ATRX) or death
domain-associated (DAXX) protein. We previously reported that alternative lengthening of
telomeres and loss of ATRX expression were common in leiomyosarcoma, angiosarcoma …
karyotype tumors. Alternative lengthening of telomeres is a telomere-maintenance
mechanism common in sarcomas. Recently, this mechanism was found to be associated
with loss of either α-thalassemia/mental retardation syndrome X-linked (ATRX) or death
domain-associated (DAXX) protein. We previously reported that alternative lengthening of
telomeres and loss of ATRX expression were common in leiomyosarcoma, angiosarcoma …