[HTML][HTML] Isoform-specific binding of selenoprotein P to the β-propeller domain of apolipoprotein E receptor 2 mediates selenium supply
S Kurokawa, FP Bellinger, KE Hill, RF Burk… - Journal of Biological …, 2014 - ASBMB
Sepp1 supplies selenium to tissues via receptor-mediated endocytosis. Mice, rats, and
humans have 10 selenocysteines in Sepp1, which are incorporated via recoding of the stop
codon, UGA. Four isoforms of rat Sepp1 have been identified, including full-length Sepp1
and three others, which terminate at the second, third, and seventh UGA codons. Previous
studies have shown that the longer Sepp1 isoforms bind to the low density lipoprotein
receptor apoER2, but the mechanism remains unclear. To identify the essential residues for …
humans have 10 selenocysteines in Sepp1, which are incorporated via recoding of the stop
codon, UGA. Four isoforms of rat Sepp1 have been identified, including full-length Sepp1
and three others, which terminate at the second, third, and seventh UGA codons. Previous
studies have shown that the longer Sepp1 isoforms bind to the low density lipoprotein
receptor apoER2, but the mechanism remains unclear. To identify the essential residues for …