Ste20-related protein kinases have been implicated as regulating a range of cellular
responses, including stress-activated protein kinase pathways and the control of cytoskeletal
architecture. An important issue involves the identities of the upstream signals and
regulators that might control the biological functions of mammalian Ste20-related protein
kinases. HPK1 is a protein-serine/threonine kinase that possesses a Ste20-like kinase
domain, and in transfected cells activates a protein kinase pathway leading to the stress …