Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity
W Kallenborn-Gerhardt, SW Hohmann, KMJ Syhr… - PAINŽ, 2014 - Elsevier
Emerging lines of evidence indicate that production of reactive oxygen species (ROS) at
distinct sites of the nociceptive system contributes to the processing of neuropathic pain.
However, the mechanisms underlying ROS production during neuropathic pain processing
are not fully understood. We here detected the ROS-generating nicotinamide adenine
dinucleotide phosphate oxidase isoform Nox2 in macrophages of dorsal root ganglia (DRG)
in mice. In response to peripheral nerve injury, Nox2-positive macrophages were recruited …
distinct sites of the nociceptive system contributes to the processing of neuropathic pain.
However, the mechanisms underlying ROS production during neuropathic pain processing
are not fully understood. We here detected the ROS-generating nicotinamide adenine
dinucleotide phosphate oxidase isoform Nox2 in macrophages of dorsal root ganglia (DRG)
in mice. In response to peripheral nerve injury, Nox2-positive macrophages were recruited …