[HTML][HTML] Transforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons
E Utreras, J Keller, A Terse, M Prochazkova… - Journal of Biological …, 2012 - ASBMB
In addition to many important roles for Cdk5 in brain development and synaptic function, we
reported previously that Cdk5 regulates inflammatory pain signaling, partly through
phosphorylation of transient receptor potential vanilloid 1 (TRPV1), an important Na+/Ca 2+
channel expressed in primary nociceptive afferent nerves. Because TGF-β regulates
inflammatory processes and its receptor is expressed in TRPV1-positive afferents, we
studied the cross-talk between these two pathways in sensory neurons during experimental …
reported previously that Cdk5 regulates inflammatory pain signaling, partly through
phosphorylation of transient receptor potential vanilloid 1 (TRPV1), an important Na+/Ca 2+
channel expressed in primary nociceptive afferent nerves. Because TGF-β regulates
inflammatory processes and its receptor is expressed in TRPV1-positive afferents, we
studied the cross-talk between these two pathways in sensory neurons during experimental …