Lysosomal integral membrane protein-2: a new player in lysosome-related pathology
A Gonzalez, M Valeiras, E Sidransky… - Molecular genetics and …, 2014 - Elsevier
Lysosomes require the presence of many specialized proteins to facilitate their roles in
cellular maintenance. One such protein that has proven to be an important player in the
lysosomal field is lysosomal integral membrane protein-2 (LIMP-2), encoded by the gene
SCARB2. LIMP-2 is required for the normal biogenesis and maintenance of lysosomes and
endosomes and has been identified as the specific receptor for glucocerebrosidase, the
enzyme deficient in Gaucher disease. Research into LIMP-2 and the SCARB2 gene indicate …
cellular maintenance. One such protein that has proven to be an important player in the
lysosomal field is lysosomal integral membrane protein-2 (LIMP-2), encoded by the gene
SCARB2. LIMP-2 is required for the normal biogenesis and maintenance of lysosomes and
endosomes and has been identified as the specific receptor for glucocerebrosidase, the
enzyme deficient in Gaucher disease. Research into LIMP-2 and the SCARB2 gene indicate …