[HTML][HTML] Analysis of tissue factor expression in various cell model systems: cryptic vs. active
H Kothari, UR Pendurthi, LVM Rao - Journal of thrombosis and …, 2013 - Elsevier
Background Tissue factor (TF) encryption plays an important role in regulating TF coagulant
activity. Potential differences in experimental cell model systems and strategies hampered
our understanding of the TF encryption mechanisms. Objective To characterize the
procoagulant activity status of TF in different cell types, and to determine whether increased
TF procoagulant activity following the activation stems from transformation of the cryptic TF to
the active form. Methods Simultaneous kinetic analyses of TF‐FVIIa activation of FX and …
activity. Potential differences in experimental cell model systems and strategies hampered
our understanding of the TF encryption mechanisms. Objective To characterize the
procoagulant activity status of TF in different cell types, and to determine whether increased
TF procoagulant activity following the activation stems from transformation of the cryptic TF to
the active form. Methods Simultaneous kinetic analyses of TF‐FVIIa activation of FX and …