Background The human upper respiratory tract is the first site of contact for inhaled
respiratory viruses and elaborates an array of innate immune responses. Seasonal variation
in respiratory viral infections and the importance of ambient temperature in modulating
immune responses to infections have been well recognized; however, the underlying
biological mechanisms remain understudied. Objective We investigated the role of nasal
epithelium-derived extracellular vesicles (EVs) in innate Toll-like receptor 3 (TLR3) …