Control of pancreas and liver gene expression by HNF transcription factors
Science, 2004•science.org
The transcriptional regulatory networks that specify and maintain human tissue diversity are
largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation
combined with promoter microarrays to identify systematically the genes occupied by the
transcriptional regulators HNF1α, HNF4α, and HNF6, together with RNA polymerase II, in
human liver and pancreatic islets. We identified tissue-specific regulatory circuits formed by
HNF1α, HNF4α, and HNF6 with other transcription factors, revealing how these factors …
largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation
combined with promoter microarrays to identify systematically the genes occupied by the
transcriptional regulators HNF1α, HNF4α, and HNF6, together with RNA polymerase II, in
human liver and pancreatic islets. We identified tissue-specific regulatory circuits formed by
HNF1α, HNF4α, and HNF6 with other transcription factors, revealing how these factors …
The transcriptional regulatory networks that specify and maintain human tissue diversity are largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation combined with promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1α, HNF4α, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets. We identified tissue-specific regulatory circuits formed by HNF1α, HNF4α, and HNF6 with other transcription factors, revealing how these factors function as master regulators of hepatocyte and islet transcription. Our results suggest how misregulation of HNF4α can contribute to type 2 diabetes.
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