[HTML][HTML] The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its …

SJ Stone, MC Levin, P Zhou, J Han, TC Walther… - Journal of Biological …, 2009 - ASBMB
The synthesis and storage of neutral lipids in lipid droplets is a fundamental property of
eukaryotic cells, but the spatial organization of this process is poorly understood. Here we
examined the intracellular localization of acyl-CoA: diacylglycerol acyltransferase 2
(DGAT2), an enzyme that catalyzes the final step of triacylglycerol (TG) synthesis in
eukaryotes. We found that DGAT2 expressed in cultured cells localizes to the endoplasmic
reticulum (ER) under basal conditions. After providing oleate to drive TG synthesis, DGAT2 …