[HTML][HTML] OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression

J Hu, L Zhang, Z Zhao, M Zhang, J Lin, J Wang… - … et Biophysica Acta (BBA …, 2017 - Elsevier
J Hu, L Zhang, Z Zhao, M Zhang, J Lin, J Wang, W Yu, W Man, C Li, R Zhang, E Gao
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2017Elsevier
The incidence and prevalence of heart failure (HF) in the world are rapidly rising possibly
attributed to the worsened HF following myocardial infarction (MI) in recent years. Here we
examined the effects of oncostatin M (OSM) on postinfarction cardiac remodeling and the
underlying mechanisms involved. MI model was induced using left anterior descending
coronary artery (LAD) ligation. In addition, cultured neonatal mouse cardiomyocytes were
subjected to simulated MI. Our results revealed that OSM alleviated left ventricular …
Abstract
The incidence and prevalence of heart failure (HF) in the world are rapidly rising possibly attributed to the worsened HF following myocardial infarction (MI) in recent years. Here we examined the effects of oncostatin M (OSM) on postinfarction cardiac remodeling and the underlying mechanisms involved. MI model was induced using left anterior descending coronary artery (LAD) ligation. In addition, cultured neonatal mouse cardiomyocytes were subjected to simulated MI. Our results revealed that OSM alleviated left ventricular remodeling, promoted cardiac function, restored mitochondrial cristae density and architecture disorders after 4 weeks of MI. Enhanced autophagic flux was indicated in cardiomyocytes transduced with Ad-GFP -LC3 in the OSM treated group as compared with the MI group. OSM receptor Oβ knockout blocked the beneficial effects of OSM in postinfarction cardiac remodeling and cardiomyocytes autophagy. OSM pretreatment significantly alleviated left ventricular remodeling and dysfunction in Mst1 transgenic mice, while it failed to reverse further the postinfarction left ventricular dilatation and cardiac function in the Mst1 knockout mice. Our data revealed that OSM alleviated postinfarction cardiac remodeling and dysfunction by enhancing cardiomyocyte autophagy. OSM holds promise as a therapeutic target in treating HF after MI through Oβ receptor by inhibiting Mst1 phosphorylation.
Elsevier