[PDF][PDF] A stiff blow from the stroma: collagen crosslinking drives tumor progression
MR Ng, JS Brugge - Cancer cell, 2009 - cell.com
MR Ng, JS Brugge
Cancer cell, 2009•cell.comMatrix stiffness is an important microenvironmental cue that regulates cell growth, motility,
and differentiation. In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-
mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to
enhanced integrin signaling and invasive behavior in tumors.
and differentiation. In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-
mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to
enhanced integrin signaling and invasive behavior in tumors.
Matrix stiffness is an important microenvironmental cue that regulates cell growth, motility, and differentiation. In a recent Cell report, Weaver and colleagues implicate lysyl-oxidase-mediated collagen crosslinking as a contributor to tumor matrix stiffening, which leads to enhanced integrin signaling and invasive behavior in tumors.
cell.com