Sodium sensing in the subfornical organ and body-fluid homeostasis
TY Hiyama, M Noda - Neuroscience Research, 2016 - Elsevier
The brain monitors conditions of body fluids and levels of circulating neuroactive factors to
maintain the systemic homeostasis. Unlike most regions in the brain, circumventricular
organs (CVOs) lack the blood–brain barrier, and serve as the sensing center. Among the
CVOs, the subfornical organ (SFO) is the sensing site of Na+ levels in body fluids to control
water and salt intake. The SFO harbors neuronal cell bodies with a variety of hormone
receptors and innervates many brain loci. In addition, the SFO harbors specialized glial cells …
maintain the systemic homeostasis. Unlike most regions in the brain, circumventricular
organs (CVOs) lack the blood–brain barrier, and serve as the sensing center. Among the
CVOs, the subfornical organ (SFO) is the sensing site of Na+ levels in body fluids to control
water and salt intake. The SFO harbors neuronal cell bodies with a variety of hormone
receptors and innervates many brain loci. In addition, the SFO harbors specialized glial cells …