Alpha2-adrenergic stimulation within the nucleus tractus solitarius attenuates vasopressin release induced by depletion of cardiovascular volume

M Iovino, A Vanacore, L Steardo - Pharmacology Biochemistry and …, 1990 - Elsevier
The functional role of the nucleus tractus solitarius (NTS) in the regulation of arginine-
vasopressin (AVP) release mediated by baroreceptor activation was investigated by
examining the effects induced by the presynaptic α-adrenergic agonist clonidine. The
present data show that microinjection of clonidine into NTS resulted in a significant
attenuation of AVP secretion induced by hypovolemia in the rat. This effect produced by NTS
injection of 8 and 10 nmol clonidine was prevented by NTS pretreatment with the α 2 …