[HTML][HTML] WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade
WNK1 is a widely expressed serine/threonine protein kinase that regulates multiple cellular
and organ functions via diverse mechanisms. We previously reported that endothelial-
specific deletion of Wnk1 in mice results in embryonic lethality, with angiogenesis and
cardiac defects beginning at embryonic day∼ 10.5. Here, we further investigated the
signaling mechanism by which WNK1 regulates embryonic cardiovascular development. We
found that mice with a global deletion of Osr1, which encodes oxidative stress-responsive …
and organ functions via diverse mechanisms. We previously reported that endothelial-
specific deletion of Wnk1 in mice results in embryonic lethality, with angiogenesis and
cardiac defects beginning at embryonic day∼ 10.5. Here, we further investigated the
signaling mechanism by which WNK1 regulates embryonic cardiovascular development. We
found that mice with a global deletion of Osr1, which encodes oxidative stress-responsive …