Metabolic associated fatty liver disease increases coronavirus disease 2019 disease severity in nondiabetic patients
F Gao, KI Zheng, XB Wang, HD Yan… - Journal of …, 2021 - Wiley Online Library
F Gao, KI Zheng, XB Wang, HD Yan, QF Sun, KH Pan, TY Wang, YP Chen, J George…
Journal of gastroenterology and hepatology, 2021•Wiley Online LibraryAbstract Background and Aim Coronavirus disease 2019 (COVID‐19) has attracted
increasing worldwide attention. While diabetes is known to aggravate COVID‐19 severity, it
is not known whether nondiabetic patients with metabolic dysfunction are also more prone to
more severe disease. The association of metabolic associated fatty liver disease (MAFLD)
with COVID‐19 severity in nondiabetic patients was investigated here. Methods The study
cohort comprised 65 patients with (ie cases) and 65 patients without MAFLD (ie controls) …
increasing worldwide attention. While diabetes is known to aggravate COVID‐19 severity, it
is not known whether nondiabetic patients with metabolic dysfunction are also more prone to
more severe disease. The association of metabolic associated fatty liver disease (MAFLD)
with COVID‐19 severity in nondiabetic patients was investigated here. Methods The study
cohort comprised 65 patients with (ie cases) and 65 patients without MAFLD (ie controls) …
Background and Aim
Coronavirus disease 2019 (COVID‐19) has attracted increasing worldwide attention. While diabetes is known to aggravate COVID‐19 severity, it is not known whether nondiabetic patients with metabolic dysfunction are also more prone to more severe disease. The association of metabolic associated fatty liver disease (MAFLD) with COVID‐19 severity in nondiabetic patients was investigated here.
Methods
The study cohort comprised 65 patients with (i.e. cases) and 65 patients without MAFLD (i.e. controls). Each case was randomly matched with one control by sex (1:1) and age (±5 years). The association between the presence of MAFLD (as exposure) and COVID‐19 severity (as the outcome) was assessed by binary logistic regression analysis.
Results
In nondiabetic patients with COVID‐19, the presence of MAFLD was associated with a four‐fold increased risk of severe COVID‐19; the risk increased with increasing numbers of metabolic risk factors. The association with COVID‐19 severity persisted after adjusting for age, sex, and coexisting morbid conditions.
Conclusion
Health‐care professionals caring for nondiabetic patients with COVID‐19 should be cognizant of the increased likelihood of severe COVID‐19 in patients with MAFLD.
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