Mortality in overweight and underweight children with acute myeloid leukemia
BJ Lange, RB Gerbing, J Feusner, J Skolnik, N Sacks… - Jama, 2005 - jamanetwork.com
ContextCurrent treatment for acute myeloid leukemia (AML) in children cures about half the
patients. Of the other half, most succumb to leukemia, but 5% to 15% die of treatment-related
complications. Overweight children with AML seem to experience excess life-threatening
and fatal toxicity. Nothing is known about how weight affects outcomes in pediatric AML.
ObjectiveTo compare survival rates in children with AML who at diagnosis are underweight
(body mass index [BMI]≤ 10th percentile), overweight (BMI≥ 95th percentile), or …
patients. Of the other half, most succumb to leukemia, but 5% to 15% die of treatment-related
complications. Overweight children with AML seem to experience excess life-threatening
and fatal toxicity. Nothing is known about how weight affects outcomes in pediatric AML.
ObjectiveTo compare survival rates in children with AML who at diagnosis are underweight
(body mass index [BMI]≤ 10th percentile), overweight (BMI≥ 95th percentile), or …