[HTML][HTML] The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection
The signaling pathways and cellular functions regulated by the four Numb-associated
kinases are largely unknown. We reported that AAK1 and GAK control intracellular trafficking
of RNA viruses and revealed a requirement for BIKE in early and late stages of dengue virus
(DENV) infection. However, the downstream targets phosphorylated by BIKE have not yet
been identified. Here, to identify BIKE substrates, we conducted a barcode fusion genetics-
yeast two-hybrid screen and retrieved publicly available data generated via affinity …
kinases are largely unknown. We reported that AAK1 and GAK control intracellular trafficking
of RNA viruses and revealed a requirement for BIKE in early and late stages of dengue virus
(DENV) infection. However, the downstream targets phosphorylated by BIKE have not yet
been identified. Here, to identify BIKE substrates, we conducted a barcode fusion genetics-
yeast two-hybrid screen and retrieved publicly available data generated via affinity …