[HTML][HTML] Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease
Parkinson disease (PD), a prevalent neurodegenerative motor disorder, is characterized by
the rather selective loss of dopaminergic neurons and the presence of α-synuclein-enriched
Lewy body inclusions in the substantia nigra of the midbrain. Although the etiology of PD
remains incompletely understood, emerging evidence suggests that dysregulated iron
homeostasis may be involved. Notably, nigral dopaminergic neurons are enriched in iron,
the uptake of which is facilitated by the divalent metal ion transporter DMT1. To clarify the …
the rather selective loss of dopaminergic neurons and the presence of α-synuclein-enriched
Lewy body inclusions in the substantia nigra of the midbrain. Although the etiology of PD
remains incompletely understood, emerging evidence suggests that dysregulated iron
homeostasis may be involved. Notably, nigral dopaminergic neurons are enriched in iron,
the uptake of which is facilitated by the divalent metal ion transporter DMT1. To clarify the …