Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors
Nature medicine, 2020•nature.com
Abstract Serum interleukin-8 (IL-8) levels and tumor neutrophil infiltration are associated
with worse prognosis in advanced cancers. Here, using a large-scale retrospective analysis,
we show that elevated baseline serum IL-8 levels are associated with poor outcome in
patients (n= 1,344) with advanced cancers treated with nivolumab and/or ipilimumab,
everolimus or docetaxel in phase 3 clinical trials, revealing the importance of assessing
serum IL-8 levels in identifying unfavorable tumor immunobiology and as an independent …
with worse prognosis in advanced cancers. Here, using a large-scale retrospective analysis,
we show that elevated baseline serum IL-8 levels are associated with poor outcome in
patients (n= 1,344) with advanced cancers treated with nivolumab and/or ipilimumab,
everolimus or docetaxel in phase 3 clinical trials, revealing the importance of assessing
serum IL-8 levels in identifying unfavorable tumor immunobiology and as an independent …
Abstract
Serum interleukin-8 (IL-8) levels and tumor neutrophil infiltration are associated with worse prognosis in advanced cancers. Here, using a large-scale retrospective analysis, we show that elevated baseline serum IL-8 levels are associated with poor outcome in patients (n = 1,344) with advanced cancers treated with nivolumab and/or ipilimumab, everolimus or docetaxel in phase 3 clinical trials, revealing the importance of assessing serum IL-8 levels in identifying unfavorable tumor immunobiology and as an independent biomarker in patients receiving immune-checkpoint inhibitors.
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