[HTML][HTML] Signal-binding specificity of the μ4 subunit of the adaptor protein complex AP-4
RC Aguilar, M Boehm, I Gorshkova, RJ Crouch… - Journal of Biological …, 2001 - ASBMB
The medium (μ) chains of the adaptor protein (AP) complexes AP-1, AP-2, and AP-3
recognize distinct subsets of tyrosine-based (YXXØ) sorting signals found within the
cytoplasmic domains of integral membrane proteins. Here, we describe the signal-binding
specificity and affinity of the medium subunit μ4 of the recently described adaptor protein
complex AP-4. To elucidate the determinants of specificity, we screened a two-hybrid
combinatorial peptide library using μ4 as a selector protein. Statistical analyses of the results …
recognize distinct subsets of tyrosine-based (YXXØ) sorting signals found within the
cytoplasmic domains of integral membrane proteins. Here, we describe the signal-binding
specificity and affinity of the medium subunit μ4 of the recently described adaptor protein
complex AP-4. To elucidate the determinants of specificity, we screened a two-hybrid
combinatorial peptide library using μ4 as a selector protein. Statistical analyses of the results …