[HTML][HTML] Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules
Vitamin D metabolism centers on kidney regulation of Cyp27b1 by mineralotropic hormones,
including induction by parathyroid hormone (PTH), suppression by fibroblast growth factor
23 (FGF23) and 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), and reciprocal regulations for
Cyp24a1. This coordinated genomic regulation results in production of endocrine 1, 25 (OH)
2 D 3, which, together with PTH and FGF23, controls mineral homeostasis. However, how
these events are coordinated is unclear. Here, using in vivo chromatin immunoprecipitation …
including induction by parathyroid hormone (PTH), suppression by fibroblast growth factor
23 (FGF23) and 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3), and reciprocal regulations for
Cyp24a1. This coordinated genomic regulation results in production of endocrine 1, 25 (OH)
2 D 3, which, together with PTH and FGF23, controls mineral homeostasis. However, how
these events are coordinated is unclear. Here, using in vivo chromatin immunoprecipitation …