[HTML][HTML] A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene Cyp24a1 in renal and non-renal tissues
MB Meyer, SM Lee, AH Carlson, NA Benkusky… - Journal of Biological …, 2019 - ASBMB
Cytochrome P450 family 27 subfamily B member 1 (CYP27B1) and CYP24A1 function to
maintain physiological levels of 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) in the kidney.
Renal Cyp27b1 and Cyp24a1 expression levels are transcriptionally regulated in a highly
reciprocal manner by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and
1, 25 (OH) 2 D 3. In contrast, Cyp24a1 regulation in nonrenal target cells (NRTCs) is limited
to induction by 1, 25 (OH) 2 D 3. Herein, we used ChIP-Seq analyses of mouse tissues to …
maintain physiological levels of 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3) in the kidney.
Renal Cyp27b1 and Cyp24a1 expression levels are transcriptionally regulated in a highly
reciprocal manner by parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and
1, 25 (OH) 2 D 3. In contrast, Cyp24a1 regulation in nonrenal target cells (NRTCs) is limited
to induction by 1, 25 (OH) 2 D 3. Herein, we used ChIP-Seq analyses of mouse tissues to …