[HTML][HTML] Cytochrome P450-mediated metabolism of vitamin D
G Jones, DE Prosser, M Kaufmann - Journal of lipid research, 2014 - ASBMB
The vitamin D signal transduction system involves a series of cytochrome P450-containing
sterol hydroxylases to generate and degrade the active hormone, 1α, 25-dihydroxyvitamin D
3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene
expression described in companion articles in this review series. This review updates our
current knowledge of the specific anabolic cytochrome P450s involved in 25-and 1α-
hydroxylation, as well as the catabolic cytochrome P450 involved in 24-and 23 …
sterol hydroxylases to generate and degrade the active hormone, 1α, 25-dihydroxyvitamin D
3, which serves as a ligand for the vitamin D receptor-mediated transcriptional gene
expression described in companion articles in this review series. This review updates our
current knowledge of the specific anabolic cytochrome P450s involved in 25-and 1α-
hydroxylation, as well as the catabolic cytochrome P450 involved in 24-and 23 …