Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1α, 25-dihydroxy Vitamin D3 and dietary Ca2+
SFJ van de Graaf, I Boullart, JGJ Hoenderop… - The Journal of Steroid …, 2004 - Elsevier
SFJ van de Graaf, I Boullart, JGJ Hoenderop, RJM Bindels
The Journal of Steroid Biochemistry and Molecular Biology, 2004•ElsevierActive, transepithelial Ca2+ transport is a pivotal process in the regulation of Ca2+
homeostasis and consists of three sequential steps: apical Ca2+ influx, diffusion towards the
basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and
TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting
influx step of transepithelial Ca2+ transport and these highly selective Ca2+ channels are
controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 …
homeostasis and consists of three sequential steps: apical Ca2+ influx, diffusion towards the
basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and
TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting
influx step of transepithelial Ca2+ transport and these highly selective Ca2+ channels are
controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 …
Active, transepithelial Ca2+ transport is a pivotal process in the regulation of Ca2+ homeostasis and consists of three sequential steps: apical Ca2+ influx, diffusion towards the basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting influx step of transepithelial Ca2+ transport and these highly selective Ca2+ channels are controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 abundance and/or activity by 1α,25-dihydroxyVitamin D3 (1α,25(OH)2D3), dietary Ca2+ and the auxiliary protein pair S100A10/annexin 2. Finally, the implications for our understanding of transcellular Ca2+ transport will be discussed.
Elsevier