[HTML][HTML] UV light potentiates STING (stimulator of interferon genes)-dependent innate immune signaling through deregulation of ULK1 (Unc51-like kinase 1)
MG Kemp, LA Lindsey-Boltz, A Sancar - Journal of Biological Chemistry, 2015 - ASBMB
The mechanism by which ultraviolet (UV) wavelengths of sunlight trigger or exacerbate the
symptoms of the autoimmune disorder lupus erythematosus is not known but may involve a
role for the innate immune system. Here we show that UV radiation potentiates STING
(stimulator of interferon genes)-dependent activation of the immune signaling transcription
factor interferon regulatory factor 3 (IRF3) in response to cytosolic DNA and cyclic
dinucleotides in keratinocytes and other human cells. Furthermore, we find that modulation …
symptoms of the autoimmune disorder lupus erythematosus is not known but may involve a
role for the innate immune system. Here we show that UV radiation potentiates STING
(stimulator of interferon genes)-dependent activation of the immune signaling transcription
factor interferon regulatory factor 3 (IRF3) in response to cytosolic DNA and cyclic
dinucleotides in keratinocytes and other human cells. Furthermore, we find that modulation …
