The liver, the major site of production of most coagulation components, is intimately involved
in the clearance of activation products. Hemostasic abnormalities relate to the extent of liver
function impairment. Minor impairment may be associated with slight decreases in clotting
factors, especially the vitamin Independent factors; major defects (cirrhosis) may display
decreases of virtually all factors, impaired platelet function, and increased consumption (ie,
disseminated intravascular coagulation [DIC]). Liver surgery invariably leads to bleeding …