[HTML][HTML] Elevated de novo lipogenesis, slow liver triglyceride turnover, and clinical correlations in nonalcoholic steatohepatitis patients
EJ Lawitz, KW Li, E Nyangau, TJ Field, JC Chuang… - Journal of lipid …, 2022 - ASBMB
De novo lipogenesis (DNL) converts carbon substrates to lipids. Increased hepatic DNL
could contribute to pathogenic liver triglyceride accumulation in nonalcoholic steatohepatitis
(NASH) and therefore may be a potential target for pharmacological intervention. Here, we
measured hepatic DNL using heavy water in 123 patients with NASH with fibrosis or
cirrhosis, calculated the turnover of hepatic triglycerides to allow repeat labeling studies, and
determined the associations of hepatic DNL with metabolic, fibrotic, and imaging markers …
could contribute to pathogenic liver triglyceride accumulation in nonalcoholic steatohepatitis
(NASH) and therefore may be a potential target for pharmacological intervention. Here, we
measured hepatic DNL using heavy water in 123 patients with NASH with fibrosis or
cirrhosis, calculated the turnover of hepatic triglycerides to allow repeat labeling studies, and
determined the associations of hepatic DNL with metabolic, fibrotic, and imaging markers …