Calcium-sensing in the kidney
P Houillier - Current opinion in nephrology and hypertension, 2013 - journals.lww.com
Current opinion in nephrology and hypertension, 2013•journals.lww.com
As the CaSR in the kidney controls calcium reabsorption and excretion and subsequently
affects blood calcium concentration, agonists and antagonists of the CaSR could be used to
control blood calcium concentration in patients who have lost their ability to regulate
parathyroid hormone secretion. In addition, more work is needed to further decipher the
molecular mechanisms through which CaSR determines calcium transport in the loop of
Henle.
affects blood calcium concentration, agonists and antagonists of the CaSR could be used to
control blood calcium concentration in patients who have lost their ability to regulate
parathyroid hormone secretion. In addition, more work is needed to further decipher the
molecular mechanisms through which CaSR determines calcium transport in the loop of
Henle.
Summary
As the CaSR in the kidney controls calcium reabsorption and excretion and subsequently affects blood calcium concentration, agonists and antagonists of the CaSR could be used to control blood calcium concentration in patients who have lost their ability to regulate parathyroid hormone secretion. In addition, more work is needed to further decipher the molecular mechanisms through which CaSR determines calcium transport in the loop of Henle.
Lippincott Williams & Wilkins