[HTML][HTML] The platelet-derived growth factor controls c-myc expression through a JNK-and AP-1-dependent signaling pathway
C Iavarone, A Catania, MJ Marinissen… - Journal of Biological …, 2003 - ASBMB
Pro-inflammatory cytokines, environmental stresses, as well as receptor tyrosine kinases
regulate the activity of JNK. In turn, JNK phosphorylates Jun members of the AP-1 family of
transcription factors, thereby controlling processes as different as cell growth, differentiation,
and apoptosis. Still, very few targets of the JNK-Jun pathway have been identified. Here we
show that JNK is required for the induction of c-myc expression by PDGF. Furthermore, we
identify a phylogenetically conserved AP-1-responsive element in the promoter of the c-myc …
regulate the activity of JNK. In turn, JNK phosphorylates Jun members of the AP-1 family of
transcription factors, thereby controlling processes as different as cell growth, differentiation,
and apoptosis. Still, very few targets of the JNK-Jun pathway have been identified. Here we
show that JNK is required for the induction of c-myc expression by PDGF. Furthermore, we
identify a phylogenetically conserved AP-1-responsive element in the promoter of the c-myc …