Roles of sterol regulatory element-binding proteins (SREBPs) have been established as
lipid synthetic transcription factors especially for cholesterol and fatty acid synthesis.
SREBPs have unique characteristics. Firstly, they are membrane-bound proteins and the N-
terminal active portions enter nucleus to activate their target genes after proteolytic
cleavage, which requires sterol-sensing molecule, SREBP-activating protein (SCAP) and is
crucial for sterol-regulation. Secondly, they bind and activate sterol-regulatory (SREs) …