Autophagy is a lysosomal degradation process crucial for adaptation to stress and cellular
homeostasis. In cancer, autophagy has been demonstrated to serve multifaceted roles in
tumor initiation and progression. Although genetic evidence corroborates a role for
autophagy as a tumor suppressor mechanism during tumor initiation, autophagy also
sustains metabolic pathways in cancer cells and promotes survival within the harsh tumor
microenvironment and in response to diverse anticancer therapies. Moreover, though …