Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging
Androgens such as testosterone and dihydrotestosterone are a critical driver of prostate
cancer progression. Cancer resistance to androgen deprivation therapies ensues when
tumors engage metabolic processes that produce sustained androgen levels in the tissue.
However, the molecular mechanisms involved in this resistance process are unclear, and
functional imaging modalities that predict impending resistance are lacking. Here, using the
human LNCaP and C4-2 cell line models of prostate cancer, we show that castration …
cancer progression. Cancer resistance to androgen deprivation therapies ensues when
tumors engage metabolic processes that produce sustained androgen levels in the tissue.
However, the molecular mechanisms involved in this resistance process are unclear, and
functional imaging modalities that predict impending resistance are lacking. Here, using the
human LNCaP and C4-2 cell line models of prostate cancer, we show that castration …
