[HTML][HTML] Context-dependent GATA factor function: combinatorial requirements for transcriptional control in hematopoietic and endothelial cells
RJ Wozniak, ME Boyer, JA Grass, Y Lee… - Journal of biological …, 2007 - ASBMB
GATA factors are fundamental components of developmentally important transcriptional
networks. By contrast to common mechanisms in which transacting factors function directly
at promoters, the hematopoietic GATA factors GATA-1 and GATA-2 often assemble
dispersed complexes over broad chromosomal regions. For example, GATA-1 and GATA-2
occupy five conserved regions over∼ 100 kb of the Gata2 locus in the transcriptionally
repressed and active states, respectively, in erythroid cells. Since it is unknown whether the …
networks. By contrast to common mechanisms in which transacting factors function directly
at promoters, the hematopoietic GATA factors GATA-1 and GATA-2 often assemble
dispersed complexes over broad chromosomal regions. For example, GATA-1 and GATA-2
occupy five conserved regions over∼ 100 kb of the Gata2 locus in the transcriptionally
repressed and active states, respectively, in erythroid cells. Since it is unknown whether the …