Transcriptional regulators mediate the genesis and function of the hematopoietic system by
binding complex ensembles of cis-regulatory elements to establish genetic networks. While
thousands to millions of any given cis-element resides in a genome, how transcriptional
regulators select these sites and how site attributes dictate functional output is not well
understood. An instructive system to address this problem involves the GATA family of
transcription factors that control vital developmental and physiological processes and are …