[HTML][HTML] Secondary structure of the human cardiac Na+ channel C terminus: evidence for a role of helical structures in modulation of channel inactivation
JW Cormier, I Rivolta, M Tateyama, AS Yang… - Journal of Biological …, 2002 - ASBMB
Little is known about the structure of the C terminus of the human cardiac voltage-gated
sodium channel α subunit (SCN5A), but disease-linked mutations within this 244-amino acid
intracellular region of the channel have marked effects on channel inactivation. Here we
report a structural analysis of the C-terminal tail of the cardiac Na+ channel that sheds new
light on mechanisms that control its inactivation gating. Homology modeling of the SCN5A C
terminus predicts predominant α-helical structure (six helices) in the proximal half of this …
sodium channel α subunit (SCN5A), but disease-linked mutations within this 244-amino acid
intracellular region of the channel have marked effects on channel inactivation. Here we
report a structural analysis of the C-terminal tail of the cardiac Na+ channel that sheds new
light on mechanisms that control its inactivation gating. Homology modeling of the SCN5A C
terminus predicts predominant α-helical structure (six helices) in the proximal half of this …