Importance Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
of the motor nervous system. Clinical studies have demonstrated cortical and spinal motor
neuron hyperexcitability using transcranial magnetic stimulation and threshold tracking
nerve conduction studies, respectively, although metrics of excitability have not been used
as pharmacodynamic biomarkers in multi-site clinical trials. Objective To ascertain whether
ezogabine decreases cortical and spinal motor neuron excitability in ALS. Design, Setting …