Role of mitochondrial DNA in septic AKI via toll-like receptor 9
N Tsuji, T Tsuji, N Ohashi, A Kato… - Journal of the …, 2016 - journals.lww.com
Abstract Toll-like receptor 9 (TLR9) contributes to the development of polymicrobial septic
AKI. However, the mechanisms that activate the TLR9 pathway and cause kidney injury
during sepsis remain unknown. To determine the role of mitochondrial DNA (mtDNA) in
TLR9-associated septic AKI, we established a cecal ligation and puncture (CLP) model of
sepsis in wild-type (WT) and Tlr9-knockout (Tlr9KO) mice. We evaluated systemic circulation
and peritoneal cavity dynamics and immune response and tubular mitochondrial dysfunction …
AKI. However, the mechanisms that activate the TLR9 pathway and cause kidney injury
during sepsis remain unknown. To determine the role of mitochondrial DNA (mtDNA) in
TLR9-associated septic AKI, we established a cecal ligation and puncture (CLP) model of
sepsis in wild-type (WT) and Tlr9-knockout (Tlr9KO) mice. We evaluated systemic circulation
and peritoneal cavity dynamics and immune response and tubular mitochondrial dysfunction …