[HTML][HTML] Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases [S]
Z Ma, JM Onorato, L Chen, DW Nelson, CLE Yen… - Journal of Lipid …, 2017 - ASBMB
In mammals, ether lipids exert a wide spectrum of signaling and structural functions, such as
stimulation of immune responses, anti-tumor activities, and enhancement of sperm functions.
Abnormal accumulation of monoalkyl-diacylglycerol (MADAG) was found in Wolman's
disease, a human genetic disorder defined by a deficiency in lysosomal acid lipase. In the
current study, we found that among the nine recombinant human lipid acyltransferases
examined, acyl-CoA: diacylglycerol acyltransferase (DGAT) 1, DGAT2, acyl-CoA …
stimulation of immune responses, anti-tumor activities, and enhancement of sperm functions.
Abnormal accumulation of monoalkyl-diacylglycerol (MADAG) was found in Wolman's
disease, a human genetic disorder defined by a deficiency in lysosomal acid lipase. In the
current study, we found that among the nine recombinant human lipid acyltransferases
examined, acyl-CoA: diacylglycerol acyltransferase (DGAT) 1, DGAT2, acyl-CoA …