[HTML][HTML] Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response
AKT is a critical effector kinase downstream of the PI3K pathway that regulates a plethora of
cellular processes including cell growth, death, differentiation, and migration. Mechanisms
underlying activated phospho-AKT (pAKT) translocation to its action sites remain unclear.
Here we show that NEDD4-1 is a novel E3 ligase that specifically regulates ubiquitin-
dependent trafficking of pAKT in insulin-like growth factor (IGF)-1 signaling. NEDD4-1
physically interacts with AKT and promotes HECT domain-dependent ubiquitination of …
cellular processes including cell growth, death, differentiation, and migration. Mechanisms
underlying activated phospho-AKT (pAKT) translocation to its action sites remain unclear.
Here we show that NEDD4-1 is a novel E3 ligase that specifically regulates ubiquitin-
dependent trafficking of pAKT in insulin-like growth factor (IGF)-1 signaling. NEDD4-1
physically interacts with AKT and promotes HECT domain-dependent ubiquitination of …