[HTML][HTML] Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells
M Bardor, DH Nguyen, S Diaz, A Varki - Journal of Biological Chemistry, 2005 - ASBMB
N-Glycolylneuraminic acid (Neu5Gc) is a widely expressed sialic acid in mammalian cells.
Although humans are genetically deficient in producing Neu5Gc, small amounts are present
in human cells in vivo. A dietary origin was suggested by human volunteer studies and by
observing that free Neu5Gc is metabolically incorporated into cultured human carcinoma
cells by unknown mechanisms. We now show that free Neu5Gc uptake also occurs in other
human and mammalian cells. Inhibitors of certain non-clathrin-mediated endocytic pathways …
Although humans are genetically deficient in producing Neu5Gc, small amounts are present
in human cells in vivo. A dietary origin was suggested by human volunteer studies and by
observing that free Neu5Gc is metabolically incorporated into cultured human carcinoma
cells by unknown mechanisms. We now show that free Neu5Gc uptake also occurs in other
human and mammalian cells. Inhibitors of certain non-clathrin-mediated endocytic pathways …