Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis
M Tidswell, W Tillis, SP LaRosa, M Lynn… - Critical care …, 2010 - journals.lww.com
Objectives: Endotoxin is a potent stimulus of proinflammatory response and systemic
coagulation in patients with severe sepsis. Endotoxin is a component of Gram-negative
bacteria that triggers an innate immune response through Toll-like receptor 4 signaling
pathways in myeloid cells. We evaluated safety and tolerability of two dose regimens of
eritoran tetrasodium (E5564), a synthetic Toll-like receptor 4 antagonist, and explored
whether it decreases 28-day mortality rate in subjects with severe sepsis. Design …
coagulation in patients with severe sepsis. Endotoxin is a component of Gram-negative
bacteria that triggers an innate immune response through Toll-like receptor 4 signaling
pathways in myeloid cells. We evaluated safety and tolerability of two dose regimens of
eritoran tetrasodium (E5564), a synthetic Toll-like receptor 4 antagonist, and explored
whether it decreases 28-day mortality rate in subjects with severe sepsis. Design …