Role of regulatory T cells in long-term immune dysfunction associated with severe sepsis
DC Nascimento, JC Alves-Filho, F Sônego… - Critical care …, 2010 - journals.lww.com
Objective: To investigate the role of regulatory T cells in the modulation of long-term immune
dysfunction during experimental sepsis. It is well established that sepsis predisposes to
development of a pronounced immunosuppression. Nevertheless, the mechanisms
underlying the immune dysfunction after sepsis are still not well understood. Design:
Prospective experimental study. Setting: University research laboratory. Interventions: Wild-
type mice underwent cecal ligation and puncture and were treated with antibiotic during 3 …
dysfunction during experimental sepsis. It is well established that sepsis predisposes to
development of a pronounced immunosuppression. Nevertheless, the mechanisms
underlying the immune dysfunction after sepsis are still not well understood. Design:
Prospective experimental study. Setting: University research laboratory. Interventions: Wild-
type mice underwent cecal ligation and puncture and were treated with antibiotic during 3 …