The HMG-I Oncogene Causes Highly Penetrant, Aggressive Lymphoid Malignancy in Transgenic Mice and Is Overexpressed in Human Leukemia
Y Xu, TF Sumter, R Bhattacharya, A Tesfaye, EJ Fuchs… - Cancer Research, 2004 - AACR
Y Xu, TF Sumter, R Bhattacharya, A Tesfaye, EJ Fuchs, LJ Wood, DL Huso, LMS Resar
Cancer Research, 2004•AACRAbstract HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in
transformation has not been established. We generated transgenic mice with HMG-I
targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive
lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are
transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human
acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene …
transformation has not been established. We generated transgenic mice with HMG-I
targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive
lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are
transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human
acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene …
Abstract
HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in transformation has not been established. We generated transgenic mice with HMG-I targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene and suggest that it contributes to the pathogenesis of leukemia and other cancers with increased HMG-I expression.
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