HMGI/Y proteins: flexible regulators of transcription and chromatin structure
R Reeves, L Beckerbauer - Biochimica et Biophysica Acta (BBA)-Gene …, 2001 - Elsevier
The mammalian HMGI/Y (HMGA) non-histone proteins participate in a wide variety of
cellular processes including regulation of inducible gene transcription, integration of
retroviruses into chromosomes and the induction of neoplastic transformation and promotion
of metastatic progression of cancer cells. Recent advances have contributed greatly to our
understanding of how the HMGI/Y proteins participate in the molecular mechanisms
underlying these biological events. All members of the HMGI/Y family of 'high mobility …
cellular processes including regulation of inducible gene transcription, integration of
retroviruses into chromosomes and the induction of neoplastic transformation and promotion
of metastatic progression of cancer cells. Recent advances have contributed greatly to our
understanding of how the HMGI/Y proteins participate in the molecular mechanisms
underlying these biological events. All members of the HMGI/Y family of 'high mobility …