Plasticity of renin cells in the kidney vasculature
RA Gomez, MLSS Lopez - Current hypertension reports, 2017 - Springer
RA Gomez, MLSS Lopez
Current hypertension reports, 2017•SpringerDuring development, renin cells are precursors for arteriolar smooth muscle, mesangial
cells, and interstitial pericytes. Those seemingly differentiated descendants retain the
memory to re-express renin when there is a threat to homeostasis. Understanding how such
molecular memory is constructed and regulated would be crucial to comprehend cell identity
which is, in turn, intimately linked to homeostasis.
cells, and interstitial pericytes. Those seemingly differentiated descendants retain the
memory to re-express renin when there is a threat to homeostasis. Understanding how such
molecular memory is constructed and regulated would be crucial to comprehend cell identity
which is, in turn, intimately linked to homeostasis.
Abstract
During development, renin cells are precursors for arteriolar smooth muscle, mesangial cells, and interstitial pericytes. Those seemingly differentiated descendants retain the memory to re-express renin when there is a threat to homeostasis. Understanding how such molecular memory is constructed and regulated would be crucial to comprehend cell identity which is, in turn, intimately linked to homeostasis.
Springer